Systemic lupus erythematosus (SLE), commonly called lupus, is a long-term autoimmune disease where the body’s immune system—meant to protect against infections—starts attacking its own healthy cells and tissues, causing widespread inflammation and damage. 1 This inflammation can affect various parts of the body including the skin, joints, blood vessels, kidneys, brain, heart, and lungs. 1 What m akes l upus so complicated ? The disease presents differently in each individual , with variations in symptom type, combination, and severity. Typically, lupus follows a pattern, with episodes of symptom flare-ups alternating with periods of remission when symptoms lessen or temporarily resolve. 1 Common Symptoms of SLE Symptoms of lupus typically appear gradually, with one or two signs emerging initially and additional or varied symptoms developing over time. Some of the most common ones include 1 : Joint pain or swelling Muscl...